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Apamin structure and pharmacology revisited

Apamin is often cited as one of the few substances selectively acting on small-conductance Ca2+-activated potassium channels (KCa2). However, published pharmacological and structural data remain controversial. Here, we investigated the molecular pharmacology of apamin by two-electrode voltage-clamp...

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Autori principali: Alexey I. Kuzmenkov, Steve Peigneur, Joshua A. Nasburg, Konstantin S. Mineev, Maxim V. Nikolaev, Ernesto Lopes Pinheiro-Junior, Alexander S. Arseniev, Heike Wulff, Jan Tytgat, Alexander A. Vassilevski
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-09-01
Serie:Frontiers in Pharmacology
Soggetti:
apamin
Apis mellifera
bee venom
calcium-activated potassium channel
ion channel
spatial structure
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2022.977440/full
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