Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation

Abstract Background Preclinical studies and early clinical trials have shown that targeting cancer neoantigens is a promising approach towards the development of personalized cancer immunotherapies. DNA vaccines can be rapidly and efficiently manufactured and can integrate multiple neoantigens simul...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W. Kim, John M. Herndon, Michelle K. Becker-Hapak, Beatriz M. Carreno, Nancy B. Myers, Mark A. Sturmoski, Michael D. McLellan, Christopher A. Miller, Tanner M. Johanns, Benjamin R. Tan, Gavin P. Dunn, Timothy P. Fleming, Ted H. Hansen, S. Peter Goedegebuure, William E. Gillanders
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2021-04-01
Serija:	Genome Medicine
Teme:	Neoantigen Polyepitope DNA vaccine Breast cancer
Online dostop:	https://doi.org/10.1186/s13073-021-00872-4
Oznake:	Označite Brez oznak, prvi označite!