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Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach

Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for vaccination against COVID-19 and for protein replacement therapies. LNPs enhance mRNA stability, circulation time, cellular uptake, and preferential delivery to specific tissues compared to mRNA with no carrier...

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Principais autores: Rachel E. Young, Katherine M. Nelson, Samuel I. Hofbauer, Tara Vijayakumar, Mohamad-Gabriel Alameh, Drew Weissman, Charalampos Papachristou, Jason P. Gleghorn, Rachel S. Riley
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2024-04-01
Serier:Bioactive Materials
Fag:
Lipid nanoparticles (LNPs)
Drug delivery
Nucleic acids
Placental growth factor (PlGF)
Placenta
Pregnancy
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452199X23003638
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