Heat shock protein 60-targeted peptide-conjugated platinum nanozyme: redox regulation by multi-enzyme activities induces mitochondrial reprogramming and acute leukemia cells fate switch

Abstract Acute myeloid leukemia (AML) is characterized by differentiation arrest and apoptosis resistance, frequently with mitochondrial dysfunction and aberrant heat shock protein 60 (HSP60) overexpression as key drivers of malignant progression. Platinum-based nanozymes exhibit multi-enzymatic act...

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מידע ביבליוגרפי

Principais autores:	Jing Yao, Yanyan Li, Yiling Meng, Tao Wang, Jie Meng, Jian Liu, Tao Wen, Haiyan Xu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2026-05-01
סדרה:	Journal of Nanobiotechnology
נושאים:	Acute myeloid leukemia Platinum nanoparticles Mitochondrial metabolic reprogramming Differentiation Apoptosis
גישה מקוונת:	https://doi.org/10.1186/s12951-026-04596-8
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!