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Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-I to assemble new fibrils. Endogenous collagen production was...

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Автори: Joan Chang, Adam Pickard, Jeremy A Herrera, Sarah O'Keefe, Richa Garva, Matthew Hartshorn, Anna Hoyle, Lewis Dingle, John Knox, Thomas A Jowitt, Madeleine Coy, Jason Wong, Adam Reid, Yinhui Lu, Cédric Zeltz, Rajamiyer V Venkateswaran, Patrick T Caswell, Stephen High, Donald Gullberg, Karl E Kadler
Формат: Artigo
Мова:Inglês
Опубліковано: eLife Sciences Publications Ltd 2025-01-01
Серія:eLife
Предмети:
collagen
fibrosis
endocytosis
integrin
fibrillogenesis
Онлайн доступ:https://elifesciences.org/articles/95842
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