Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which increases the incidence of colorectal cancer (CRC). In the pathophysiology of IBD, ubiquitination/deubiquitination plays a critical regulatory function. Josephin domain containing 2 (JOSD2), a de...

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Principais autores:	Xin Liu, Yi Fang, Mincong Huang, Shiliang Tu, Boan Zheng, Hang Yuan, Peng Yu, Mengyao Lan, Wu Luo, Yongqiang Zhou, Guorong Chen, Zhe Shen, Yi Wang, Guang Liang
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-02-01
Serija:	Acta Pharmaceutica Sinica B
Teme:	Colitis Deubiquitinase JOSD2 IMPDH2 Inflammation Inflammatory bowel disease
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211383524004702
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