Reduction of canine plasminogen leads to an expanded molecule which precipitates.
Canine plasminogen is made up of seven domains. In each domain there are several cysteines that are linked by disulfide bonds. Reduction of a limited number of the cystines destabilizes the protein such that it precipitates. The bond or bonds that are broken provide about 14 kcal of stabilization en...
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| Hovedforfatter: | |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science (PLoS)
2009-07-01
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| Serier: | PLoS ONE |
| Online adgang: | http://europepmc.org/articles/PMC2703797?pdf=render |
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