GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization

Abstract Background Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from pathogenic influenza infection in mice, but the mechanisms of protection...

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Detalhes bibliográficos

Principais autores:	E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage, Zissis C. Chroneos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-01-01
coleção:	Respiratory Research
Assuntos:	Influenza GM-CSF Macrophage Alveolar Exudative Pneumonia
Acesso em linha:	http://link.springer.com/article/10.1186/s12931-017-0708-5
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