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CYP3A Genotype Is Associated With Variability in the Exposure and Clearance of the Novel Oncogenic Transcription Inhibitor Lurbinectedin

ABSTRACT Lurbinectedin is an oncogenic transcription inhibitor indicated for the treatment of small cell lung cancer (SCLC), which has also shown activity against other malignancies. In this work, two independent cohorts of 180 (discovery cohort) and 719 (validation cohort) cancer patients receiving...

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Principais autores: Rubin Lubomirov, Laura Pérez‐Ramos, Salvador Fudio, Eduardo Asín‐Prieto, Laura Ibarra‐Gómez, Pablo Zubiaur
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-04-01
Serier:Clinical and Translational Science
Fag:
cancer
CYP3A4
CYP3A5
lurbinectedin
pharmacogenetics
pharmacokinetics
Online adgang:https://doi.org/10.1111/cts.70173
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