Examining predictors of scale-up penalty in preliminary studies of health behavior interventions and subsequent larger trials: a meta-epidemiological review of diverse fields

Abstract Background Scale-up penalty, a common phenomenon in which the promising effects found in early preliminary studies are substantially reduced when evaluated in a subsequent larger trial, can stall the advancement of health behavior interventions. In obesity-related behavioral interventions,...

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Autores principales:	Lauren von Klinggraeff, Christopher D. Pfledderer, Sarah Burkart, Kaitlyn Ramey, Michal Smith, Alexander C. McLain, Bridget Armstrong, R. Glenn Weaver, Anthony Okely, David Lubans, John P. A. Ioannidis, Russell Jago, Gabrielle Turner-McGrievy, James Thrasher, Xiaoming Li, Michael W. Beets
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-05-01
Colección:	Pilot and Feasibility Studies
Acceso en línea:	https://doi.org/10.1186/s40814-026-01836-4
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