Inhibitor binding mode and allosteric regulation of Na + -glucose symporters
Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2018-12-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-018-07700-1 |
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