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The prenylated pUS2 protein of pseudorabies virus contributes to phosphorylation of connexin 43 and suppression of gap junctional intercellular communication

ABSTRACT Gap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We previously showed that the alphaherpesvirus pseudorabies vi...

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Principais autores: Alexander Tishchenko, Benjamin De Boeck, Cliff Van Waesberghe, Fien van Raemdonck, Walter Fuchs, Barbara G. Klupp, Thomas C. Mettenleiter, Oliver Vickman, Gregory A. Smith, Herman W. Favoreel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-07-01
Serier:Journal of Virology
Fag:
pseudorabies virus
gap junctions
US2
prenylation
ERK1/2
alphaherpesvirus
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00773-26
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