Heterogeneous Folding Intermediates Govern the Conformational Pathway of the RNA Recognition Motif Domain of the Ewing Sarcoma Protein

The RNA Recognition Motif (RRM) domain of the Ewing sarcoma (EWS) protein plays a pivotal role in RNA binding and gene regulation, being crucial for its function. However, its structural dynamics are yet to be revealed. Herein, we performed 5.5 μs cumulative molecular dynamics (MD) simulations to in...

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Detalhes bibliográficos

Principais autores:	Priyanka Kataria, Vishakha Chaudhary, Chandra Bhushan Mishra, Vijay Kumar, Ravi Datta Sharma, Amresh Prakash
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-12-01
coleção:	Biomolecules
Assuntos:	RRM EWS MD simulation free-energy landscape GMM urea
Acesso em linha:	https://www.mdpi.com/2218-273X/16/1/33
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