Aurora kinase A drives non-canonical YAP1/TAZ crosstalk to sustain primary resistance to anti-EGFR therapies in colorectal cancer

Anti-epidermal growth factor receptor (EGFR) therapies are the most recommended first-line treatment for RAS/RAF wild-type unresectable metastatic colorectal cancer (CRC) according to the European Society for Medical Oncology guidelines. However, primary resistance renders this treatment ineffective...

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Главные авторы:	Anxo Rio-Vilariño, Ana Garcia-Bautista, Aiora Cenigaonandia-Campillo, Pedro A. Mateos-Gomez, Laura Garcia-Garcia, Marina I. Schlaepfer, Laura Garcia-Hernandez, Laura del Puerto-Nevado, Oscar Aguilera, Natalia Baños, Pablo Minguez, Víctor Manuel Castellano, Jesús Garcia-Foncillas, Arancha Cebrian
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-09-01
Серии:	Molecular Therapy: Oncology
Предметы:	anti-EGFR Aurora kinase A cancer stem cells cetuximab drug resistance metastatic colorectal cancer
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2950329925001018
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