Berberine Derivatives as <i>Pseudomonas aeruginosa</i> MexXY-OprM Inhibitors: Activity and In Silico Insights

The natural alkaloid berberine has been demonstrated to inhibit the <i>Pseudomonas aeruginosa</i> multidrug efflux system MexXY-OprM, which is responsible for tobramycin extrusion by binding the inner membrane transporter MexY. To find a structure with improved inhibitory activity, we compared by mo...

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Principais autores:	Giorgia Giorgini, Gianmarco Mangiaterra, Nicholas Cedraro, Emiliano Laudadio, Giulia Sabbatini, Mattia Cantarini, Cristina Minnelli, Giovanna Mobbili, Emanuela Frangipani, Francesca Biavasco, Roberta Galeazzi
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-11-01
Serija:	Molecules
Teme:	efflux pump inhibitors <i>Pseudomonas aeruginosa</i> berberine derivatives molecular modeling multidrug resistance
Online dostop:	https://www.mdpi.com/1420-3049/26/21/6644
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