Driving p53 Response to Bax Activation Greatly Enhances Sensitivity to Taxol by Inducing Massive Apoptosis

The proapoptotic gene bax is one of the downstream effectors of p53. The p53 binding site in the bax promoter is less responsive to p53 than the one in the growth arrest mediating gene p21. We introduced the bax gene under the control of 13 copies of a strong p53 responsive element into two ovarian...

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Hlavní autoři:	Paola De Feudis, Sara Vignati, Cosmo Rossi, Tatiana Mincioni, Raffaella Giavazzi, Maurizio D'Incalci, Massimo Broggini
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2000-05-01
Edice:	Neoplasia: An International Journal for Oncology Research
Témata:	apoptosis p53 anticancer agents tumor xenografts transcription
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1476558600800299
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