Characterization of preclinical radio ADME properties of ARV-471 for predicting human PK using PBPK modeling

Proteolysis-targeting chimeras (PROTACs) represent a promising class of drugs that can target disease-causing proteins more effectively than traditional small molecule inhibitors can, potentially revolutionizing drug discovery and treatment strategies. However, the links between in vitro and in vivo...

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Auteurs principaux:	Yifei He, Chenggu Zhu, Peng Lei, Chen Yang, Yifan Zhang, Yuandong Zheng, Xingxing Diao
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2025-05-01
Collection:	Journal of Pharmaceutical Analysis
Sujets:	PROTAC Vepdegestrant (ARV-471) Radiolabeling In vitro–in vivo extrapolation (IVIVE) Physiologically based pharmacokinetic (PBPK) model
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2095177924002727
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