Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies

Despite the high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, its full capacity is currently limited by the generation of dysfunctional CAR T cells. Senescent or exhausted CAR T cells possess poor targeting and effector functions, as well as impaired cell pro...

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Detalhes bibliográficos

Principais autores:	Katia Beider, Orit Itzhaki, Jacob Schachter, Ania Hava Grushchenko-Polaq, Valeria Voevoda-Dimenshtein, Evgenia Rosenberg, Olga Ostrovsky, Olivia Devillers, Ronnie Shapira Frommer, Li-at Zeltzer, Amos Toren, Elad Jacoby, Avichai Shimoni, Abraham Avigdor, Arnon Nagler, Michal J. Besser
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-03-01
coleção:	Cells
Assuntos:	CAR T B cell malignancies exhaustion resistance molecular signature
Acesso em linha:	https://www.mdpi.com/2073-4409/11/7/1140
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