Modeling HIV-1 drug resistance as episodic directional selection.
The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in frequency over time. While methods exist to detect episodic diversifying selection...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2012-01-01
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| Serie: | PLoS Computational Biology |
| Accesso online: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22589711/?tool=EBI |
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