Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

Abstract Background Although WD repeat domain 45 (WDR45) mutations have been linked to $$\upbeta$$ β -propeller protein-associated neurodegeneration (BPAN), the precise molecular and cellular mechanisms behind this disease remain elusive. This study aims to shed light on the impacts of WDR45-deficie...

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Principais autores:	Panpan Wang, Yaping Shao, Murad Al-Nusaif, Jun Zhang, Huijia Yang, Yuting Yang, Kunhyok Kim, Song Li, Cong Liu, Huaibin Cai, Weidong Le
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-08-01
coleção:	Molecular Neurodegeneration
Assuntos:	WDR45 Axonal degeneration Autophagy Tubular ER Phospholipid metabolism Lpcat1
Acesso em linha:	https://doi.org/10.1186/s13024-024-00746-4
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