Marine-Inspired Ovothiol Analogs Inhibit Membrane-Bound Gamma-Glutamyl-Transpeptidase and Modulate Reactive Oxygen Species and Glutathione Levels in Human Leukemic Cells

The enzyme γ-glutamyl transpeptidase (GGT), located on the surface of cellular membranes, hydrolyzes extracellular glutathione (GSH) to guarantee the recycling of cysteine and maintain intracellular redox homeostasis. High expression levels of GGT on tumor cells are associated with increased cell pr...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Annalisa Zuccarotto, Maria Russo, Annamaria Di Giacomo, Alessandra Casale, Aleksandra Mitrić, Serena Leone, Gian Luigi Russo, Immacolata Castellano
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-07-01
coleção:	Marine Drugs
Assuntos:	ovothiols 5-thiohistidine gamma-glutamyl-transpeptidase glutathione GGT inhibitors leukemic cells
Acesso em linha:	https://www.mdpi.com/1660-3397/23/8/308
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!