The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.

In female fruit flies, Sex-lethal (Sxl) turns off the X chromosome dosage compensation system by a mechanism involving a combination of alternative splicing and translational repression of the male specific lethal-2 (msl-2) mRNA. A genetic screen identified the translation initiation factor eif4e as...

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Hlavní autoři:	Patricia L Graham, Judith L Yanowitz, Jill K M Penn, Girish Deshpande, Paul Schedl
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2011-07-01
Edice:	PLoS Genetics
On-line přístup:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002185&type=printable
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