HPCAL1 promotes colorectal cancer progression via TCF7/p65-mediated Wnt ligand upregulation and Wnt/β-catenin pathway activation

Abstract Abnormal Wnt/β-catenin pathway activation drives colorectal cancer (CRC) tumorigenesis, yet effective targeted therapies remain elusive. Given HPCAL1’s established dual tumor-suppressive and oncogenic roles in other cancers, this study investigates its function in CRC to assess the therapeu...

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Auteurs principaux:	Linna Cheng, Huiyang Zhang, Liqun Guo, Qing Zhang, Yuanyuan Zhang, Qi Xie, Shuai Zhou, Dongpeng Wen, Wenchao Chen, Zhikai Wang, Jiancheng Zhang, Rick F. Thorne, Zunmin Zhu
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2026-05-01
Collection:	Oncogenesis
Accès en ligne:	https://doi.org/10.1038/s41389-026-00618-0
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