Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

Abstract Background The advents of novel immunotherapies have revolutionized the treatment of cancer. Adoptive cellular therapies using chimeric antigen receptor T (CAR-T) cells have achieved remarkable clinical responses in B cell leukemia and lymphoma but the effect on solid tumors including lung...

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Principais autores:	Junlin Yao, Dalam Ly, Dzana Dervovic, Linan Fang, Jong Bok Lee, Hyeonjeong Kang, Yu-Hui Wang, Nhu-An Pham, Hongming Pan, Ming-Sound Tsao, Li Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 2019-01-01
coleção:	Journal for ImmunoTherapy of Cancer
Assuntos:	Adoptive cellular therapy Double negative T cells Lung cancer IL-15
Acesso em linha:	http://link.springer.com/article/10.1186/s40425-019-0507-2
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