Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1
Abstract High urate levels in circulation lead to the accumulation of urate crystals in joints and ultimately inflammation and gout. The reabsorption process of urate in the kidney by the urate transporter URAT1 plays a pivotal role in controlling serum urate levels. Pharmacological inhibition of UR...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Acceso en liña: | https://doi.org/10.1038/s41467-025-56843-5 |
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