Lack of GNAQ and GNA11 germ-line mutations in familial melanoma pedigrees with uveal melanoma or blue nevi

Approximately 10% of melanoma cases are familial, but only 25-40% of familial melanoma cases can be attributed to germ-line mutations in the CDKN2A - the most significant high-risk melanoma susceptibility locus identified to date. The pathogenic mutation(s) in most of the remaining familial melanoma...

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Hlavní autoři:	Jason Ezra Hawkes, Jennifer eCampbell, Daniel eGarvin, Lisa eCannon Albright, Pamela eCassidy, Sancy A Leachman
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2013-06-01
Edice:	Frontiers in Oncology
Témata:	Uveal Melanoma familial melanoma GNAQ GNA11 germ-line blue nevi
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00160/full
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