Physicochemical properties and cytochromes P-450 kinetics of the trifluoroacetamido derivative of phenacetin
Substituting hydrogen atoms with fluorine alters physicochemical properties often resulting in improved drug action relative to the parent molecule. The high electronegativity of fluorine changes the electron density distribution of the molecule; however, the substitution does not significantly chan...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2025-01-01
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| Serija: | Results in Chemistry |
| Teme: | |
| Online pristup: | http://www.sciencedirect.com/science/article/pii/S2211715624006143 |
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