p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Abstract Background Malignant pleural mesothelioma (MPM) is an orphan disease that is difficult to treat using traditional chemotherapy, an approach which has been effective in other types of cancer. Most chemotherapeutics cause DNA damage leading to cell death. Recent discoveries have highlighted a...

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Detalhes bibliográficos

Principais autores:	Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, Hasen Alhebshi, Parisa Meysami, Constantinos Demonacos, Jean-Marc Schwartz, Luciano Mutti, Marija Krstic-Demonacos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-10-01
coleção:	Journal of Translational Medicine
Assuntos:	Drug repositioning Bioinformatics Mesothelioma TP53 Personalized medicine
Acesso em linha:	http://link.springer.com/article/10.1186/s12967-018-1650-0
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