Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning
Abstract Background Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to deregulation of degron functionality disrupt control of protein abundance due to mistargeting of proteins destined fo...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2022-07-01
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| Serie: | BMC Biology |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s12915-022-01364-6 |
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