Myeloid AMPK signaling restricts fibrosis but is not required for metformin improvements during CDAHFD-induced NASH in mice

Metabolic programming underpins inflammation and liver macrophage activation in the setting of chronic liver disease. Here, we sought to identify the role of an important metabolic regulator, AMP-activated protein kinase (AMPK), specifically within myeloid cells during the progression of non-alcohol...

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Autori principali:	Julia R.C. Nunes, Conor O’Dwyer, Peyman Ghorbani, Tyler K.T. Smith, Samarth Chauhan, Victoria Robert-Gostlin, Madison D. Girouard, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-06-01
Serie:	Journal of Lipid Research
Soggetti:	non-alcoholic steatohepatitis NASH AMPK macrophage liver immunometabolism
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227524000695
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