Can First-Dose Therapeutic Drug Monitoring Predict the Steady State Area Under the Blood Concentration-Time Curve of Busulfan in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation?

Busulfan has high intra-individual variability and possible time-dependent changes in clearance, which complicates therapeutic drug monitoring (TDM), as first dose sampling may not predict the steady state concentrations. In this study, we aimed to use Bayesian pharmacokinetic parameters estimated f...

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Principais autores:	Abdullah Alsultan, Ahmed A. Albassam, Abdullah Alturki, Abdulrahman Alsultan, Mohammed Essa, Bader Almuzzaini, Salman Alfadhel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-04-01
coleção:	Frontiers in Pediatrics
Assuntos:	busulfan pharmacokinetics TDM (therapeutic drug monitoring) Bayesian pharmacokinetics area under the blood concentration-time curve (AUC)
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fped.2022.834773/full
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