PAMAM-cRGD mediating efficient siRNA delivery to spermatogonial stem cells

Abstract Background Spermatogonial stem cells (SSCs) are the cornerstone of sperm production and thus perpetual male fertility. In clinics, transplantation of patient’s own SSCs into testes is a promising technique to restore fertility when male germ cells have been depleted by gonadotoxic therapies...

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Bibliographic Details

Main Authors:	Tianjiao Li, Qiwen Chen, Yi Zheng, Pengfei Zhang, Xiaoxu Chen, Junna Lu, Yinghua Lv, Shiguo Sun, Wenxian Zeng
Format:	Artigo
Language:	Inglês
Published:	BMC 2019-12-01
Series:	Stem Cell Research & Therapy
Subjects:	PAMAM-cRGD siRNA delivery Nanoparticle Spermatogonial stem cells
Online Access:	https://doi.org/10.1186/s13287-019-1506-4
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