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Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model

Abstract Background Osteoarthritis (OA), a degenerative disease with a high global prevalence, is characterized by the degradation of the extracellular matrix (ECM) and the apoptosis of chondrocytes. Ajugol, a extract derived from the herb Rehmannia glutinosa, has not yet been investigated for its p...

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Principais autores: Jingtao Wu, Heng Yu, Yangcan Jin, Jingquan Wang, Liwen Zhou, Teng Cheng, Zhao Zhang, Binghao Lin, Jiansen Miao, Zhongke Lin
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2023-09-01
Series:Chinese Medicine
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Acceso en liña:https://doi.org/10.1186/s13020-023-00824-7
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