Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys

Karyomegalic interstitial nephritis (KIN) is a genetic adult-onset chronic kidney disease (CKD) characterized by genomic instability and mitotic abnormalities in the tubular epithelial cells. KIN is caused by recessive mutations in the FAN1 DNA repair enzyme. However, the endogenous source of DNA da...

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Bibliografiska uppgifter

Huvudupphov:	Merlin Airik, Haley Arbore, Elizabeth Childs, Amy B. Huynh, Yu Leng Phua, Chi Wei Chen, Katherine Aird, Sivakama Bharathi, Bob Zhang, Peter Conlon, Stanislav Kmoch, Kendrah Kidd, Anthony J. Bleyer, Jerry Vockley, Eric Goetzman, Peter Wipf, Rannar Airik
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2023-04-01
Serie:	Antioxidants
Ämnen:	FAN1 karyomegalic interstitial nephritis DNA damage oxidative stress chronic kidney disease
Länkar:	https://www.mdpi.com/2076-3921/12/4/900
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