Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway

Abstract Background Ischemia-reperfusion (IR) affects microRNA (miR) expression and causes substantial inflammation. Multiple roles of the tumor suppressor miR-129-5p in cerebral IR have recently been reported, but its functions in the spinal cord are unclear. Here, we investigated the role of miR-1...

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Detalhes bibliográficos

Principais autores:	Xiao-Qian Li, Feng-Shou Chen, Wen-Fei Tan, Bo Fang, Zai-Li Zhang, Hong Ma
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-10-01
coleção:	Journal of Neuroinflammation
Assuntos:	Blood-spinal cord barrier High-mobility group box-1 Ischemia-reperfusion injury MicroRNAs Toll-like receptor 3
Acesso em linha:	http://link.springer.com/article/10.1186/s12974-017-0977-4
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