A Thermosensitive Bi‐Adjuvant Hydrogel Triggers Epitope Spreading to Promote the Anti‐Tumor Efficacy of Frameshift Neoantigens

Abstract Tumor‐specific frameshift mutations encoding peptides (FSPs) are highly immunogenic neoantigens for personalized cancer immunotherapy, while their clinical efficacy is limited by immunosuppressive tumor microenvironment (TME) and self‐tolerance. Here, a thermosensitive hydrogel (FSP‐RZ‐BPH)...

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Detalhes bibliográficos

Principais autores:	Yaohua Ke, Kai Xin, Yaping Tao, Lin Li, Aoxing Chen, Jingyi Shao, Junmeng Zhu, Dinghu Zhang, Lanqi Cen, Yanhong Chu, Lixia Yu, Baorui Liu, Qin Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2024-04-01
coleção:	Advanced Science
Assuntos:	cGAS‐STING agonist frameshift neoantigens thermosensitive hydrogel TLR7/8 agonist tumor immunotherapy
Acesso em linha:	https://doi.org/10.1002/advs.202306889
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