Assessment of the blood–brain barrier in CNS drug discovery
A wide variety of models have been developed over the years to predict blood–brain barrier (BBB) penetration, most of them have focussed on predicting total concentrations of drug and then expressing this as a brain:blood (or plasma) ratio. This approach is somewhat flawed and fails to address the c...
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| Автори: | , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Elsevier
2010-01-01
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| Серія: | Neurobiology of Disease |
| Предмети: | |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S0969996109002113 |
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