Small-molecule RAS/RAF inhibitors target RAS-driven cancers via allosteric RAF disruption

Abstract RAS, a frequently mutated cancer-driver gene, has been the focus of intensive research, with numerous inhibitors developed to target RAS and its signalling molecules. With the advent of approved subtype-specific RAS inhibitors targeting KRASG12C mutation, the development of RAS inhibitors t...

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Detalhes bibliográficos

Principais autores:	Yoko Yoshikawa, Hirokazu Kubota, Shigeyuki Matsumoto, Yoshiteru Makino, Takashi Kawamura, Hitomi Yuki, Naoki Sakai, Akira Shibaike, Megumi Okamura, Wakako Fujimoto-Sakisaka, Kou Honda, Taisuke Horikawa, Ichiro Mori, Morihito Okada, Manabu Horikawa, Kazumasa Horie, Michiyo Koyanagi-Aoi, Takashi Aoi, Tohru Kataoka, Tomoyo Okada, Atsuo Tamura, Teruki Honma, Takashi Kumasaka, Hiroo Koyama, Fumi Shima
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-08-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-76337-2
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