Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury

Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant types of cell death that largely account for the development of cardiac ischemia reperfusion injury (IRI). Here, we explored the effect of Ripk3 on mitochondrial apoptosis. Compared with wild-type mice, the infarcted...

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Autors principals:	Hao Zhou, Pingjun Zhu, Jun Guo, Nan Hu, Shuyi Wang, Dandan Li, Shunying Hu, Jun Ren, Feng Cao, Yundai Chen
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2017-10-01
Col·lecció:	Redox Biology
Matèries:	Ripk3 Necroptosis Mitochondria Apoptosis FUNDC1 Mitophagy Cardiac reperfusion injury
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2213231717304251
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