MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation

Abstract Methyl-CpG-binding protein 2 (MeCP2) is a clinically important epigenetic reader that is essential for neuronal function, but how it binds methylated DNA within the protein-DNA complexes that comprise chromatin is unclear. Using designer nucleosomes, we observe that MeCP2 is able to engage...

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Bibliografiske detaljer

Principais autores:	James A. Watson, Beatrice K. Alexander-Howden, Theo S. Hall, Martin A. Wear, Finlay McGhie, Gillian Clifford, Hannah Wapenaar, Juan Zou, Adrian Bird, Marcus D. Wilson
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-04-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-026-71741-0
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