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Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model

Abstract Background Treatment of head and neck squamous cell carcinoma (HNSCC) remains challenging and the survival rates of affected patients remain poor. A three-dimensional organotypic co-culture (3D-OTC) model where patient derived tumor tissue is cultured on human-derived fibroblasts (dermal eq...

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Principais autores: Fabian Stögbauer, Tobias Weiser, Ali Bashiri Dezfouli, Johannes Wirth, Luca Engelmann, Jan Budczies, Iordanis Ourailidis, Melanie Boxberg, Katharina Pigorsch, Benedikt Schmidl, Nicole Strittmatter, Katja Steiger, Carolin Mogler, Barbara Wollenberg
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-04-01
coleção:BMC Medicine
Assuntos:
Head and neck cancer
in vitro model
morphology
tumor budding
microenvironment
longitudinal analysis
Acesso em linha:https://doi.org/10.1186/s12916-026-04883-z
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