Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

Src-family kinases Fyn and Lyn are signaling components downstream of ITAM-bearing antigen receptors. Here the authors show that by phosphorylating SHP-1 at different residues, Lyn and Fyn can have opposing regulatory effects on ITAM receptors.

Dades bibliogràfiques

Autors principals:	Sanae Ben Mkaddem, Amaya Murua, Héloise Flament, Dimitri Titeca-Beauport, Carine Bounaix, Luca Danelli, Pierre Launay, Marc Benhamou, Ulrich Blank, Eric Daugas, Nicolas Charles, Renato C. Monteiro
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2017-08-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-017-00294-0
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