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Development and experimental validation of hypoxia-related gene signatures for osteosarcoma diagnosis and prognosis based on WGCNA and machine learning

Abstract Osteosarcoma (OS) is the most common primary malignant tumour of the bone with high mortality. Here, we comprehensively analysed the hypoxia signalling in OS and further constructed novel hypoxia-related gene signatures for OS prediction and prognosis. This study employed Gene Set Enrichmen...

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Autori principali: Bo Wen, Jian Chen, Tianqi Ding, Zhiyou Mao, Rong Jin, Yirui Wang, Meiqin Shi, Lixun Zhao, Asang Yang, Xianyun Qin, Xuewei Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-08-01
Serie:Scientific Reports
Soggetti:
Osteosarcoma
Hypoxia
Diagnosis
Prognosis
WGCNA
LASSO
Accesso online:https://doi.org/10.1038/s41598-024-69638-3
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