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Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway

Abstract Background Cancer-associated fibroblasts (CAFs) and vasculogenic mimicry (VM) play important roles in the occurrence and development of tumors. However, the relationship between CAFs and VM formation, especially in gallbladder cancer (GBC) has not been clarified. In this study, we investiga...

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Principais autores: Mu-Su Pan, Hui Wang, Kamar Hasan Ansari, Xin-Ping Li, Wei Sun, Yue-Zu Fan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-11-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
Gallbladder neoplasm
Gallbladder cancer-associated fibroblasts
Vasculogenic mimicry
NOX4
Signaling pathway
Prognosis
Online adgang:http://link.springer.com/article/10.1186/s13046-020-01742-4
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