Acquired resistance during adoptive cell therapy by transcriptional silencing of immunogenic antigens

Immunotherapies such as adoptive cell therapy (ACT) are promising treatments for solid cancers. However, relapsing disease remains a problem and the molecular mechanisms underlying resistance are poorly defined. We postulated that the deregulated epigenetic landscape in cancer cells could underpin t...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ben Wylie, Jonathan Chee, Catherine A Forbes, Mitchell Booth, Shane R Stone, Anthony Buzzai, Ana Abad, Bree Foley, Mark N Cruickshank, Jason Waithman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2019-08-01
Schriftenreihe:	OncoImmunology
Schlagworte:	cancer immunotherapy adoptive cell therapy acquired resistance epigenetic modifiers immunoediting transcriptional silencing
Online-Zugang:	http://dx.doi.org/10.1080/2162402X.2019.1609874
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!