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Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing

Osimertinib, which is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is an important anticancer drug because of its high efficacy and excellent safety profile. However, resistance against osimertinib is inevitable; therefore, therapeutic strategies to overcome the res...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Shuhei Suzuki, Masahiro Yamamoto, Tomomi Sanomachi, Keita Togashi, Asuka Sugai, Shizuka Seino, Masashi Okada, Takashi Yoshioka, Chifumi Kitanaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-08-01
Schriftenreihe:Biomedicines
Schlagworte:
drug resistance
doxazosin
osimertinib
autophagy
drug repositioning
drug repurposing
Online-Zugang:https://www.mdpi.com/2227-9059/8/8/273
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