Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway

Abstract Background Cancer-associated fibroblasts (CAFs) have been widely reported to promote tumor angiogenesis. However, the underlying mechanisms of the proangiogenic switch of CAFs remain poorly understood. This study aims to clarify the mechanisms underlying the proangiogenic switch of CAFs. Me...

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Päätekijät:	Xiaocheng Zhou, Tinglin Yan, Chunming Huang, Zhi Xu, Lin Wang, Erhui Jiang, Hui Wang, Yang Chen, Ke Liu, Zhe Shao, Zhengjun Shang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2018-10-01
Sarja:	Journal of Experimental & Clinical Cancer Research
Aiheet:	Exosomes Melanoma Cancer-associated fibroblasts Angiogenesis Mmu-miR-155-5p JAK2/STAT3 signaling pathway
Linkit:	http://link.springer.com/article/10.1186/s13046-018-0911-3
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