HLA Class II Immunogenetic Profiles Shape Psychosis Outcomes in Cannabis Users: DRB5/DRB1*16 Vulnerability and DRB4/DRB3-Linked Protection, Particularly Against Schizophrenia

Background: Only a subset of cannabis users develop persistent psychosis, implying that genetic vulnerability modulates risk. HLA-DR/DQ variation is a strong non-dopaminergic risk locus for schizophrenia, but its role in cannabis-related psychosis is unclear. Methods: We studied 296 cannabis users f...

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Principais autores:	Andrei Buciuta, Horia George Coman, Bogdan Nemeș, Mihaela Elvira Cimpianu, Radu Oroian, Mihaela Laura Vică Matei, Horea-Vladi Matei
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-05-01
Colecção:	NeuroSci
Assuntos:	cannabis psychotic disorders schizophrenia HLA class II immunogenetics genetic susceptibility
Acesso em linha:	https://www.mdpi.com/2673-4087/7/3/56
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