Huntingtin lowering impairs the maturation and synchronized synaptic activity of human cortical neuronal networks derived from induced pluripotent stem cells

Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) responsible for Huntington's disease (HD). This non...

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Príomhchruthaitheoirí:	Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	Elsevier 2024-10-01
Sraith:	Neurobiology of Disease
Ábhair:	Neuronal network HTT lowering Huntington disease Huntingtin Pluripotent stem cell Synapse
Rochtain ar líne:	http://www.sciencedirect.com/science/article/pii/S0969996124002304
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