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A Polysaccharide-RBD-Fc-Conjugated COVID-19 Vaccine, SCTV01A, Showed High Immunogenicity and Low Toxicity in Animal Models

We previously developed a polysaccharide-–RBD-conjugated nanoparticle vaccine which induced protective efficacy against SARS-CoV-2 in a mouse model. Here, we newly developed a vaccine, SCTV01A, by chemically conjugating recombinant SARS-CoV-2 RBD-Fc and PPS14 (<i>Streptococcus pneumoniae</i> serotyp...

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Autori principali: Chunyun Sun, Desheng Kong, Erhong Guo, Jun Zhao, Jilei Jia, Rui Wang, Juan Ma, Meng Chen, Jianbo Lu, Chulin Yu, Kuokuo Li, Liangzhi Xie
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2023-02-01
Serie:Vaccines
Soggetti:
COVID-19
SARS-CoV-2
conjugated vaccine
immunogenicity
toxicity
Accesso online:https://www.mdpi.com/2076-393X/11/3/526
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